| Steroid Induced Apoptosis in Rabbit Achilles tendon and NIH 3T3 , Foreskin Fibroblasts |
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Kwan Hee Lee,Sung Dae Kim,Seok Myun Ko,Joung Yoon Lee,Kyoung Back Choi,In Suk Oh |
| 가토 아킬레스건과 NIH 3T3 및 Foreskin 섬유아 세포의 스테로이드에 의한 아포토시스 |
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이관희,김성대,고석면,이정윤,최경백,오인석 |
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| Abstract |
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To evaluate the safety of repeated steroid injection in vivo in relation to apoptosis, we did staining for apoptosis and flow cytometric analysis in rabbit achilles tendon and NIH 3T3, foreskin fibroblasts after exposure to steroid. Three different concentrations of steroid were exposed to NIH 3T3 cells and foreskin fibroblasts. Rabbit achilles tendons were also injected with steroid serially. Apoptosis was not observed in most of the concentrations of steroid in NIH 3T3 cells and foreskin fibroblasts in vitro. Apoptosis was not found in NIH 3T3 cells and foreskin fibroblasts with flow cytometric analysis. But in repeated injections of steroid to rabbit achilles tendons, apoptosis was observed. We concluded that even though single dose of steroid is safe from inducing apoptosis, care must be taken for the repeated injections of steroid because it can induce apoptosis in vivo. |
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