Arch Hand Microsurg 2018; 23(2): 126-137  
Effects of a Temperature-sensitive, Anti-adhesive Agent on the Clinical Outcome of Carpal Tunnel Release Surgery
Soo Min Cha, Hyun Dae Shin
Department of Orthopedic Surgery, Daejeon Rheumatoid and Degenerative Arthritis Center, Chungnam National University Hospital, Chungnam National University School of Medicine, Daejeon, Korea
Correspondence to: Hyun Dae Shin
Department of Orthopedic Surgery, Chungnam National University School of Medicine, 266 Munhwa-ro, Jung-gu, Daejeon 35015, Korea
TEL: +82-42-280-7349, FAX: +82-42-252-7098, E-mail:
Received: April 12, 2018; Revised: April 18, 2018; Accepted: April 22, 2018; Published online: June 1, 2018.
© Korean Society for Surgery of the Hand, Korean Society for Microsurgery, and Korean Society for Surgery of the Peripheral Nerve. All rights reserved.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Purpose: We investigated the anti-adhesive effects of a temperature-sensitive poloxamer/alginate mixture (Guardix-SG®; Hanmi Medicare Inc., Korea) through a prospective randomized controlled study for carpal tunnel release surgery.
Methods: The 47 patients who received the infusion were classified as Group 1, and the 51 patients who did not were classified as Group 2. Basic demographic factors and preoperative clinical status were evaluated. At the postoperative 18 months, the degree of clinical recovery and adhesion around the median nerve for both groups were evaluated and compared using sonography.
Results: The clinical outcomes, which were assessed using the six-item carpal tunnel symptoms scale, were not significantly different between the groups. However, sonography showed that adhesions around the median nerve were significantly less common in the infusion group.
Conclusion: Although the anti-adhesive effects of the temperature-sensitive Guardix-SG® were apparent upon radiological investigation, its use was not associated with a significant difference in clinical outcome on the short-term period follow-up.
Keywords: Carpal tunnel syndrome, Transverse carpal ligament, Anti-adhesive agent

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